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This observation is intriguing for two other causes. initial, it implies that cells will take up MIF by ENDOCYTOSIS. provided the ample intracellular expression of MIF, it would be requested what advantage would the mobile achieve by utilizing endocytosed MIF instead of intracellular MIF. Endocytosis of MIF may well happen both in a very receptor-d
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MIF has emerged just lately as an important effector molecule with the innate immune technique. Unlike most cytokines, MIF is expressed constitutively by immune and endocrine cells, and likewise from the epithelial lining of tissues in direct contact with the exterior surroundings, indicating a role for MIF for a regulator of host responses to an i